GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs9387478 | 1 | rs1321799 | chr6:117731177 | ROS1 | chr6:117609530-117747018:- | 0.14 | 4.5 | 7.4E-6 | Lung cancer |
| BRCA | cis | rs12524865 | 1 | rs13218281 | chr6:134193714 | TCF21 | chr6:134210259-134219157:+ | 0.16 | 4.13 | 3.92E-5 | Coronary heart disease |
| BRCA | cis | rs13191362 | 1 | rs13218900 | chr6:163081638 | PACRG | chr6:163148164-163736523:+ | 0.26 | 4.58 | 5.14E-6 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13220048 | chr6:163004325 | PACRG | chr6:163148164-163736523:+ | 0.24 | 4.45 | 9.5E-6 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13220181 | chr6:163004401 | PACRG | chr6:163148164-163736523:+ | 0.21 | 4.14 | 3.82E-5 | Body mass index |
| BRCA | cis | rs41266839 | 1 | rs13220495 | chr6:26441640 | BTN3A2 | chr6:26365398-26378546:+ | -0.83 | -14.1 | 1.67E-41 | Schizophrenia |
| BRCA | cis | rs41266839 | 1 | rs13220495 | chr6:26441640 | ZNF391 | chr6:27356524-27369227:+ | 0.24 | 3.58 | 0.000361 | Schizophrenia |
| BRCA | cis | rs9475752 | 1 | rs13220510 | chr6:56779141 | BEND6 | chr6:56819773-56892138:+ | -0.33 | -8.92 | 2.04E-18 | Menarche (age at onset) |
| BRCA | cis | rs9475752 | 1 | rs13220510 | chr6:56779141 | KIAA1586 | chr6:56911384-56920021:+ | -0.18 | -3.66 | 0.000265 | Menarche (age at onset) |
| BRCA | cis | rs2243480 | 1 | rs13220979 | chr7:65363204 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 6.88 | 1.01E-11 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13220979 | chr7:65363204 | LOC493754 | chr7:65993446-66057363:- | 0.21 | 3.51 | 0.000474 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13220979 | chr7:65363204 | ZNF117 | chr7:64434830-64467121:- | -0.27 | -4.9 | 1.11E-6 | Diabetic kidney disease |
| BRCA | cis | rs6583954 | 1 | rs1322179 | chr10:96575242 | HELLS | chr10:96305543-96361855:+ | 0.12 | 3.38 | 0.000739 | Migraine |
| BRCA | cis | rs1322512 | 1 | rs1322512 | chr6:152947953 | VIP | chr6:153071933-153080898:+ | 0.12 | 4.04 | 5.66E-5 | Tonometry |
| BRCA | cis | rs11976180 | 1 | rs13226728 | chr7:143746578 | ARHGEF35 | chr7:143883677-143892736:- | -0.4 | -10.1 | 5.67E-23 | Obesity-related traits |